Mesenteric pseudocysts are benign lesions with an unknown etiology. They can present with a moving mass in the abdomen, abdominal pain, or even acute abdomen. Gastrointestinal stromal tumors, mucinous cystadenoma, lymphangioma, endometriosis, mesenteric panniculitis, hydatid cyst, dermoid cyst, and peritoneal cyst should be considered in the differential diagnosis. A 50-year-old female with hypertension and diabetes mellitus presented at the emergency room with intermittent abdominal pain. Contrast-enhanced magnetic resonance imaging revealed a cystic mass 5 cm in size in the left abdominal region. Laparoscopic exploration was performed and the mass was observed to the right of the ligament of Treitz above the jejunal mesentery. The mass was excised laparoscopically. Analysis of a frozen section indicated benign lesions. The patient was discharged on the second postoperative day without any complications. There were no problems observed at the 6-month follow-up. Mesenteric pseudocysts are usually benign lesions and can be excised laparoscopically.Keywords: Laparoscopic excision, mesenteric; pseudocyst.