Effect of sleeve gastrectomy on histopathological changes in the gastric mucosa

INTRODUCTION: This study aimed to evaluate the impact of weight loss on the histopathological findings of gastric mucosa in patients who underwent laparoscopic sleeve gastrectomy (LSG).
METHODS: Patients who underwent LSG for morbid obesity in our clinic between January 2019 and December 2023 were included in the study. The LSG specimen data were recorded as the surgical group (SG), and the postoperative 6-month endoscopic gastric biopsy data from the same patients were recorded as the biopsy group (BG). The two groups were compared in terms of body mass index (BMI) and histopathological observations of Helicobacter pylori (HP), chronic active gastritis (CAG), chronic inactive gastritis (CIG), and intestinal metaplasia (IM).
RESULTS: A total of 86 patients were included in the study. The median BMI was 44.00 (6.05) in the SG and 34.80 (6.00) in the BG, indicating a statistically significant difference between the groups in terms of BMI (p<0.001). Histopathological examination revealed no significant differences between the groups in terms of CAG, CIG, and IM (p>0.05). However, a significant difference was observed between the groups regarding HP (p<0.001).
DISCUSSION AND CONCLUSION: It was observed that weight loss did not lead to significant changes in histopathological findings such as CAG, CIG, and IM in the gastric mucosa, but it did result in significant differences in terms of HP.