Prognostic value of pan-immune inflammation value in patients with ulcerative colitis

INTRODUCTION: A novel index called the pan-immune inflammation value (PIV) reflects the body’s systemic inflammation and immunological response. This study aimed to determine whether the PIV can be used as a diagnostic biomarker in assessing disease activity in patients with ulcerative colitis (UC).
METHODS: According to the Truelove and Witts criteria, this retrospective study included 64 clinically active UC patients and 64 UC patients in remission. For the differential diagnosis of active UC pa-tients from patients in remission, the cut-off value was estimated by making receiver-operator curves (ROC) of PIV, platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR).
RESULTS: There were no significant differences between the active UC patients and UC patients in remis-sion regarding demographic characteristics such as age and gender. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), NLR, PLR, and PIV were significantly elevated in active UC patients than those in remission (p<0.001). According to ROC curve analysis, PIV had the greatest predictive accuracy for active UC (358.37 was the optimal PIV cut-off for active UC) with specificity and sensitivity of 71.9% and 73.4%, respectively (AUC: 0.821, p<0.001).
DISCUSSION AND CONCLUSION: PIV can be accepted as a promising marker that contributes to the evaluation of disease acti-vation/remission and severity for ulcerative colitis.

Keywords: Ulcerative colitis, pan-immune inflammation value, biomarker, disease activity, remissionathartics, postoperative complications

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