INTRODUCTION: We aimed to evaluate the effects of the addition of probiotics containing Lactobacillus acidophilus + Bifidobacterium animalis Subsp lactis to the classic triple treatment protocol (lansoprozole + amoxycillin + clarithromycin) on the success of Helicobacter pylori eradication and antibiotic side effects.
METHODS: Standard therapy (lansoprozole + amoxycillin + clarithromycin), and probiotics containing in addition to standard therapy were determined. Patients in both groups were treated for 14 days. The prebiotic, containing two different strains, was in capsule form and used twice a day. We demonstrated the helicobacter eradication status by looking at the helicobacter antigen from the stool. Statistical analyzes between the two groups were made using the pearson Chi-square test. P<0.05 was accepted as the significance level.
RESULTS: The rate of discontinuing treatment due to side effects was 15.3% in group 1, this rate was 4.5% in group 2. When double probiotics were added to the treatment, it was observed that there was a decrease of 11.2% in serious side effects (p<0.001). After the completion of the treatments. It was observed that helicobacter eradication was achieved in 152 out of 222 patients (68%) in group 1 and in 214 (89%) of 240 patients in group 2. When double probiotics were added to the treatment, it was observed that the success of eradication increased by 21% (p<0.001).
DISCUSSION AND CONCLUSION: Combined use of probiotic increases helicobacter eradication in addition to reducing the side effects of antibiotics due to H. pylori.